Difference between revisions of "Vestibular Mutant Mice"
Jump to navigation
Jump to search
(created page) |
(added video link) |
||
| (2 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
| + | Locmotor Response to 14.1 T Magnetic Field Exposure: [https://doi.org/10.5281/zenodo.7884035] | ||
== Phenotyping == | == Phenotyping == | ||
| − | A swim test was used to phenotype ''het'' mice, ''tlt'' mice, and their littermates. | + | A swim test was used to phenotype ''het'' mice, ''tlt'' mice, and their littermates. Wildtype mice (+/+) swam toward the side of the pool. Homozygous ''het'' mice (''het''/''het'') and ''tlt'' mice (''tlt''/''tlt'') were identified by their inability to swim while keeping their head above water; instead, they swam in circles and somersault towards underwater. Heterozygotes (''het''/+ or ''tlt''/+) were identified by an intermediate phenotype. |
== ''het'' == | == ''het'' == | ||
| − | spontaneous mutation B6 x STOCK Nox3<sup>het</sup>/J, Common name: head-tilt | + | spontaneous mutation B6 x STOCK ''Nox3<sup>het</sup>''/J, Common name: head-tilt |
[https://www.jax.org/strain/000061 Strain #000061] | [https://www.jax.org/strain/000061 Strain #000061] | ||
| Line 16: | Line 17: | ||
| − | B6.Cg-Otop1<sup>tlt</sup>/J, Common Name: tilted | + | B6.Cg-''Otop1<sup>tlt</sup>''/J, Common Name: tilted |
[https://www.jax.org/strain/001104 Strain #001104] | [https://www.jax.org/strain/001104 Strain #001104] | ||
[https://www.jax.org/Protocol?stockNumber=001104&protocolID=28738 Sequencing protocol] | [https://www.jax.org/Protocol?stockNumber=001104&protocolID=28738 Sequencing protocol] | ||
Latest revision as of 18:19, 1 May 2023
Locmotor Response to 14.1 T Magnetic Field Exposure: [1]
Phenotyping
A swim test was used to phenotype het mice, tlt mice, and their littermates. Wildtype mice (+/+) swam toward the side of the pool. Homozygous het mice (het/het) and tlt mice (tlt/tlt) were identified by their inability to swim while keeping their head above water; instead, they swam in circles and somersault towards underwater. Heterozygotes (het/+ or tlt/+) were identified by an intermediate phenotype.
het
spontaneous mutation B6 x STOCK Nox3het/J, Common name: head-tilt
tlt
B6.Cg-Otop1tlt/J, Common Name: tilted