Difference between revisions of "MBG Selenate Lying on Belly"
(Creating wiki page for LOB experiments) |
(added to background) |
||
| Line 5: | Line 5: | ||
[[Selenium|Sodium Selenate]] (Na2Se04) activates PP2A (1). | [[Selenium|Sodium Selenate]] (Na2Se04) activates PP2A (1). | ||
| − | + | [[CTA and Selenate]] experiments show that male Sprague Dawley rats given systemic injections of 0.5mg/kg sodium selenate two hours before taste aversion conditioning form attenuated taste aversions that extinguish rapidly. Selenate also decreases LiCl-induced phospho-MAP kinase in the NTS and lateral PBN. | |
| + | |||
| + | Results suggest that selenate interferes with the regulation of learning-induced intracellular signaling by PP2A, and prevents consolidation of memories acquired during CTA learning. However, an alternative explanation is that sodium selenate affects LiCl-induced malaise and prevents the rats from associating the conditioned stimulus (saccharin taste) with LiCl by dampening the effects of LiCl toxicity. | ||
=Agenda= | =Agenda= | ||
| + | |||
=Results= | =Results= | ||
Revision as of 10:46, 29 June 2023
Selenate modulation of LiCl-induced Lying-on-Belly
Background
Sodium Selenate (Na2Se04) activates PP2A (1).
CTA and Selenate experiments show that male Sprague Dawley rats given systemic injections of 0.5mg/kg sodium selenate two hours before taste aversion conditioning form attenuated taste aversions that extinguish rapidly. Selenate also decreases LiCl-induced phospho-MAP kinase in the NTS and lateral PBN.
Results suggest that selenate interferes with the regulation of learning-induced intracellular signaling by PP2A, and prevents consolidation of memories acquired during CTA learning. However, an alternative explanation is that sodium selenate affects LiCl-induced malaise and prevents the rats from associating the conditioned stimulus (saccharin taste) with LiCl by dampening the effects of LiCl toxicity.
Agenda
Results
References
Corcoran NM, Martin D, Hutter-Paier B, Windisch M, Nguyen T, Nheu L, Sundstrom LE, Costello AJ, Hovens CM. Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer’s disease model. Journal of Clinical Neuroscience 17: 1025- 1033, 2010.[1]
People
Marena Bass