Difference between revisions of "Vestibular Mutant Mice"
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== Phenotyping == | == Phenotyping == | ||
| − | A swim test was used to phenotype ''het'' mice, ''tlt'' mice, and their littermates. | + | A swim test was used to phenotype ''het'' mice, ''tlt'' mice, and their littermates. Wildtype mice (+/+) swam toward the side of the pool. Homozygous ''het'' mice (''het''/''het'') and ''tlt'' mice (''tlt''/''tlt'') were identified by their inability to swim while keeping their head above water; instead, they swam in circles and somersault towards underwater. Heterozygotes (''het''/+ or ''tlt''/+) were identified by an intermediate phenotype. |
== ''het'' == | == ''het'' == | ||
Revision as of 15:31, 17 December 2021
Phenotyping
A swim test was used to phenotype het mice, tlt mice, and their littermates. Wildtype mice (+/+) swam toward the side of the pool. Homozygous het mice (het/het) and tlt mice (tlt/tlt) were identified by their inability to swim while keeping their head above water; instead, they swam in circles and somersault towards underwater. Heterozygotes (het/+ or tlt/+) were identified by an intermediate phenotype.
het
spontaneous mutation B6 x STOCK Nox3het/J, Common name: head-tilt
tlt
B6.Cg-Otop1tlt/J, Common Name: tilted