Difference between revisions of "Vestibular Mutant Mice"
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== ''het'' == | == ''het'' == | ||
| − | spontaneous mutation B6 x STOCK Nox3<sup>het</sup>/J, Common name: head-tilt | + | spontaneous mutation B6 x STOCK ''Nox3<sup>het</sup>''/J, Common name: head-tilt |
[https://www.jax.org/strain/000061 Strain #000061] | [https://www.jax.org/strain/000061 Strain #000061] | ||
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| − | B6.Cg-Otop1<sup>tlt</sup>/J, Common Name: tilted | + | B6.Cg-''Otop1<sup>tlt</sup>''/J, Common Name: tilted |
[https://www.jax.org/strain/001104 Strain #001104] | [https://www.jax.org/strain/001104 Strain #001104] | ||
[https://www.jax.org/Protocol?stockNumber=001104&protocolID=28738 Sequencing protocol] | [https://www.jax.org/Protocol?stockNumber=001104&protocolID=28738 Sequencing protocol] | ||
Revision as of 14:33, 17 December 2021
Phenotyping
A swim test was used to phenotype het mice, tlt mice, and their littermates. Wildtype mice (+/+) swam toward the side of the pool. Homozygous het mice (het/het) and tlt mice (tlt/tlt) were identified by their inability to swim while keeping their head above water; instead, they swam in circles and somersault towards underwater. Heterozygotes (het/+ or tlt/+) were identified by an intermediate phenotype.
het
spontaneous mutation B6 x STOCK Nox3het/J, Common name: head-tilt
tlt
B6.Cg-Otop1tlt/J, Common Name: tilted