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JCC Clozapine-N-Oxide Taste Aversion (view source)
Revision as of 14:59, 7 March 2023
, 14:59, 7 March 2023added start dates
Arrived 2023-2-6.
Arrived 2023-2-6.
'''Day 0: Water removed''' (????)
'''Day 0: Water removed''' (2023-3-4)
'''Days 1 - 11: Water Restriction''' (???? - ????)
'''Days 1 - 11: Water Restriction''' (2023-3-5 - ????)
Weigh mice daily. Ad lib food. Water access on consecutive days at ????: 3h, 3h, 3h, 1h, 1h, 1h, 30min, 30 min, 10 min, 10 min, 10 min.
Weigh mice daily. Ad lib food. Water access on consecutive days at noon: 3h, 3h, 3h, 1h, 1h, 1h, 30min, 30 min, 10 min, 10 min, 10 min.
Note: Daylight saving time started March 12, so noon -> 1pm
Mice given water bottle and empty bottle, alternating position.
Mice given water bottle and empty bottle, alternating position.
In the afternoon, mice will be given a supplemental access to water for 30 min.
In the afternoon (~5pm) , mice will be given a supplemental access to water for 30 min.
'''Day 12: Conditioning Day''' (????)
'''Day 12: Conditioning Day''' (????)
Mice are given 10 min access to 0.125% saccharin solution, then injected with vehicle (?? ml/kg) or 0.1, 0.2 or 0.4 mg/kg [SUBJECT TO REVISION]
Mice are given 10-min access to 0.125% saccharin solution, then injected with vehicle (?? ml/kg) or 0.1, 0.2 or 0.4 mg/kg [SUBJECT TO REVISION]
Groups:
Groups:
* JCC01-04: Male, vehicle
* JCC05-08: Male, CNO
* JCC09-12: Female, vehicle
* JCC13-16: Female, CNO
After injection , ad lib water returned overnight.
After injection , ad lib water returned overnight.