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Retinoic Acid Toxicity (view source)
Revision as of 22:15, 23 February 2009
, 22:15, 23 February 2009no edit summary
42 days of treatment, daily dose of 30 mg/kg p.o. reduced BW in Zucker rats, 100 mg/kg (p.o.) reduced BW in lean rats. (also decreased plasma insulin, increased triglycerides, decreased T4). Decrease in Zucker rats due to decrease meal size with no change in frequency (conclude therefore it is not aversive). ICV administration (30 µg/rat/day) decreased BW and plasma insulin, but did not increase triglycerides or decrease T4.
42 days of treatment, daily dose of 30 mg/kg p.o. reduced BW in Zucker rats, 100 mg/kg (p.o.) reduced BW in lean rats. (also decreased plasma insulin, increased triglycerides, decreased T4). Decrease in Zucker rats due to decrease meal size with no change in frequency (conclude therefore it is not aversive). ICV administration (30 µg/rat/day) decreased BW and plasma insulin, but did not increase triglycerides or decrease T4.
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[[Category:Depression]]