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JCC Clozapine-N-Oxide Taste Aversion (view source)
Revision as of 12:58, 23 March 2023
, 12:58, 23 March 2023fixed dates
'''Days 1 - 11: Water Restriction''' (2023-3-5 - ????)
'''Days 1 - 11: Water Restriction''' (2023-3-5 - 2023-3-15)
Weigh mice daily. Ad lib food. Water access on consecutive days at noon: 3h, 3h, 3h, 1h, 1h, 1h, 30min, 30 min, 10 min, 10 min, 10 min.
Weigh mice daily. Ad lib food. Water access on consecutive days at noon: 3h, 3h, 3h, 1h, 1h, 1h, 30min, 30 min, 10 min, 10 min, 10 min.
'''Day 12: Conditioning Day''' (????)
'''Day 12: Conditioning Day''' (2023-3-16)
Mice are given 10-min access to 0.125% saccharin solution, then injected with vehicle (?? ml/kg) or 0.1, 0.2 or 0.4 mg/kg [SUBJECT TO REVISION]
Mice are given 10-min access to 0.125% saccharin solution, then injected with vehicle (?? ml/kg) or 0.1, 0.2 or 0.4 mg/kg [SUBJECT TO REVISION]
After injection , ad lib water returned overnight.
After injection , ad lib water returned overnight.
'''Day 13 - 24: Preference Tests''' (???? - ???? )
'''Day 13 - 24: Preference Tests''' (2023-3-17 - 2023-3-24 )
CTA acquisition and extinction was measured with 24-h, 2-bottle preference tests. Mice were given 24-h free access to both 0.125% saccharin and water bottles, alternating position for 10 days.
CTA acquisition and extinction was measured with 24-h, 2-bottle preference tests. Mice were given 24-h free access to both 0.125% saccharin and water bottles, alternating position for 7 days.