1,044
edits
Changes
DMV Valproate 100mg/kg Controls (view source)
Revision as of 12:28, 21 December 2022
, 12:28, 21 December 2022updated dates
Fill in some saline controls for Valproate enhancement of saccharin-LiCl CTA.
Fill in of some saline controls for Valproate enhancement of saccharin-LiCl CTA.
{{Infobox experiment|align=right
{{Infobox experiment|align=right
| protocol = 202200000006
| protocol = 202200000006
| funding = Chair's Fund
| funding = Chair's Fund
| investigators = Mukherjee, Bass, Houpt
| investigators = Mukherjee, Houpt
| species = rat
| species = rat
| date = 2022-12-1
| date = 2022-12-1
| type = CTA
| type = CTA
| drugs = valproate, lithium
| drugs = NaCl, lithium
| artifacts =
| artifacts =
| data = https://houptlab.org/bartab/expt/?id=DMV
| data = https://houptlab.org/bartab/expt/?id=DMV
==People==
==People==
Durba Mukherjee (in absentia)
Durba Mukherjee (in absentia)
'''Rats arrive (2202-11-22)'''
'''Rats arrive (2202-11-22)'''
Sprague Dawley rats (dob males: 2022-???; females: 2022-???? )
Sprague Dawley rats (dob females: 2022-9-22; males: 2022-9-26 )
'''Day 0: Water removed 2022-12-1'''
'''Day 0: Water removed 2022-12-10'''
<br>
<br>
'''Days 1-8: Water Restriction 2022-12-2 thru 2022-12-9'''
'''Days 1-10: Water Restriction 2022-12-11 thru 2022-12-20'''
Weigh rats daily. Water for 10 min, ad lib food.
Weigh rats daily. Water for 10 min, ad lib food.
<br>
<br>
'''Day 9: Conditioning Day 2022-12-10'''
'''Day 11: Conditioning Day 2022-12-21'''
* -15 min: 8 ml/kg of 0.15M LiCl
* -15 min: 8 ml/kg of 0.15M LiCl
Groups:
Groups:
* DMV01-04 NaCl-Li-Male
* DMV01-04 NaCl-NaCl-Female
* DMV05-08 NaCl-NaCl-Male
* DMV05-08 NaCl-LiCl-Female
* DMV09-12 NaCl-Li-Female
* DMV09-12 NaCl-NaCl-Male
* DMV13-16 NaCl-NaCl-Female
* DMV13-16 NaCl-LiCl-Male
<br>
<br>
'''Days 10-21: Preference Tests: 2022-12-11 to 2022-12-23'''
'''Days 12-23: Preference Tests: 2022-12-22 to 2023-1-4'''
Rats CTA acquisition and extinction was measured with 24-h, 2-bottle preference tests (for 12 days). Rats were given 24-h free access to both 0.125% saccharin and water bottles, alternating position for 10 days.
Rats CTA acquisition and extinction was measured with 24-h, 2-bottle preference tests (for 12 days). Rats were given 24-h free access to both 0.125% saccharin and water bottles, alternating position for 10 days.