Changes

==Sodium Selenate==

==Sodium Selenate==

[http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=en&N4=S8295|SIGMA&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC Sigma-Aldrich S8295-10G] $56

[https://www.sigmaaldrich.com/US/en/product/sigma/s8295 Sigma-Aldrich S8295-10G] $56

CAS Number: 13410-01-0

CAS Number: 13410-01-0

MDL number: MFCD00003490

MDL number: MFCD00003490

PubChem Substance ID: [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=24899787 24899787]

PubChem Substance ID: [https://pubchem.ncbi.nlm.nih.gov/substance/24899787 24899787]

Abdo (1994) reported on the effects of administering sodium selenate in the drinking water for 13 weeks. It was estimated that the "no-observed adverse level" in rat was 0.4 mg/kg per day of sodium selenate for 13 weeks. Doses of 0.6 mg/kg or 1.1 mg/kg  per day for 13 weeks caused changes in mortality, body weight depression, decreased water consumption, and renal papillary lesions. However, these were chronic studies so that rats received a total dose of 54.6 mg/kg or 100.1 mg/kg sodium selenate over 13 weeks.

Abdo (1994) reported on the effects of administering sodium selenate in the drinking water for 13 weeks. It was estimated that the "no-observed adverse level" in rat was 0.4 mg/kg per day of sodium selenate for 13 weeks. Doses of 0.6 mg/kg or 1.1 mg/kg  per day for 13 weeks caused changes in mortality, body weight depression, decreased water consumption, and renal papillary lesions. However, these were chronic studies so that rats received a total dose of 54.6 mg/kg or 100.1 mg/kg sodium selenate over 13 weeks.

Aasif Mandvi ran a [http://www.cc.com/video-clips/jucn2a/the-daily-show-with-jon-stewart-a-simple-plot story] on selenium pollution of Idaho rivers as a consequence of phosphate mining.

Aasif Mandvi ran a [https://www.cc.com/video/jucn2a/the-daily-show-with-jon-stewart-a-simple-plot story] on selenium pollution of Idaho rivers as a consequence of phosphate mining.

==Selenium Ingestion and Aversions==

==Selenium Ingestion and Aversions==

==Government Documents on Selenium Safety==

==Government Documents on Selenium Safety==

National Toxicology Program / NIEHS: [http://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox038.pdf NTP Technical Report on Toxicity Studies of Sodium Selenate and Sodium Selenite] (1994)

National Toxicology Program / NIEHS: [https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox038.pdf NTP Technical Report on Toxicity Studies of Sodium Selenate and Sodium Selenite] (1994)

CDC/NIOSH: [http://www.cdc.gov/niosh/idlh/7782492.html Selenium compounds (as Se)] from NIOSH Documentation for immediately dangerous to life or health concentrations (IDLHs)

CDC/NIOSH: [https://www.cdc.gov/niosh/idlh/7782492.html Selenium compounds (as Se)] from NIOSH Documentation for immediately dangerous to life or health concentrations (IDLHs)

WHO: [http://www.inchem.org/documents/ehc/ehc/ehc58.htm Environmental Health Criteria 58: Selenium] (1987) from International Programme on Chemical Safety

WHO: [https://inchem.org/documents/ehc/ehc/ehc58.htm Environmental Health Criteria 58: Selenium] (1987) from International Programme on Chemical Safety

HHS: [http://www.atsdr.cdc.gov/ToxProfiles/tp92.pdf Toxicological Profile for Selenium] (2003)

HHS: [https://www.atsdr.cdc.gov/ToxProfiles/tp92.pdf Toxicological Profile for Selenium] (2003)

Agency for Toxic Substances and Disease Registry: [http://www.atsdr.cdc.gov/toxfaqs/tf.asp?id=152&tid=28 ToxFAQs for Selenium] (2003)

Agency for Toxic Substances and Disease Registry: [https://wwwn.cdc.gov/TSP/ToxFAQs/ToxFAQsDetails.aspx?faqid=152&toxid=28 ToxFAQs for Selenium] (2003)

Agency for Toxic Substances and Disease Registry: [http://www.atsdr.cdc.gov/toxguides/toxguide-92.pdf ToxGuide for Selenium]

Agency for Toxic Substances and Disease Registry: [https://www.atsdr.cdc.gov/toxguides/toxguide-92.pdf ToxGuide for Selenium]

Division 9 of NRDC: [http://www.dtic.mil/dtic/tr/fulltext/u2/234270.pdf Chemical Warfare Agents and Related Chemical Problems, Parts I-II, Chapter 11] (1946)

Division 9 of NRDC: [https://apps.dtic.mil/dtic/tr/fulltext/u2/234270.pdf Chemical Warfare Agents and Related Chemical Problems, Parts I-II, Chapter 11] (1946)

==References==

==References==

Corcoran NM et al. 2010b.  Open-label, phase I dose-escalation study of sodium selenate, a novel activator of PP2A, in patients with castration-resistant prostate cancer. Br J Cancer. 103:462-8. PMID 20648008

Corcoran NM et al. 2010b.  Open-label, phase I dose-escalation study of sodium selenate, a novel activator of PP2A, in patients with castration-resistant prostate cancer. Br J Cancer. 103:462-8. PMID 20648008

Mandvi, A. A Simple Plot. The Daily Show with Jon Stewart, aired June 14, 2012. http://www.cc.com/video-clips/jucn2a/the-daily-show-with-jon-stewart-a-simple-plot

Mandvi, A. A Simple Plot. The Daily Show with Jon Stewart, aired June 14, 2012. https://www.cc.com/video/jucn2a/the-daily-show-with-jon-stewart-a-simple-plot

Reid ME et al.  2004 A report of high-dose selenium supplementation: response and toxicities. J Trace Elem Med Biol 18:69–74 PMID 15487766

Reid ME et al.  2004 A report of high-dose selenium supplementation: response and toxicities. J Trace Elem Med Biol 18:69–74 PMID 15487766

van Eersel J et al. 2010. Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. PNAS 107:13888-93. PMID 20643941

van Eersel J et al. 2010. Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. PNAS 107:13888-93. PMID 20643941