View source for DMG Sodium Butyrate and Saccharin-LiCl CTA

Replication (to increase N) of [[DMF Sodium Butyrate and Saccharin-LiCl CTA]]

{{Infobox experiment|align=right
| Name = Butyrate and Lithium-CTA pt2
| project = Histone Acetylation
| code = DMG
| protocol = 1917
| funding = Chair's Fund
| investigators = Mukherjee, Houpt
| species = rat
| date = 2020-11-9
| type = CTA
| drugs = butyrate, lithium
| data = https://houptlab.org/bartab/expt/?id=DMG
}}


Test if systemic Sodium Butyrate (NaB), an HDAC inhibitor, enhances CTA learning .

A more strict replication of [https://houptlab.org/papers/pdfs/Houpt065.pdf Kwon and Houpt, Brain Research, 1333 (2010) 36–47], PMID: 20346924 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871962/ PMCID: PMC2871962].

1. Ordered brand new Sodium Butyrate ([https://www.sigmaaldrich.com/US/en/product/aldrich/303410 Sigma-Aldrich 303410-100G] Butyric acid sodium salt, 98% ).

2. n=8 male, n=8 female, counterbalanced


Dose of NaB based on [https://houptlab.org/papers/pdfs/Houpt065.pdf Kwon and Houpt, Brain Research, 1333 (2010) 36–47], PMID: 20346924 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871962/ PMCID: PMC2871962] 

* 0.3 M Na Butyrate = 3.3g/100ml water
* 0.3 M NaCl = 18g/liter water (osmotic control)

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