Changes

The hair cells of the peripheral vestibular apparatus can be destroyed by the intratympanic injection of sodium arsanilate. Under halothane anesthesia, sodium arsanilate (15 mg/50 µl) is injected bilaterally with a 33 gauge needle through the tympanic membrane.  

The hair cells of the peripheral vestibular apparatus can be destroyed by the intratympanic injection of sodium arsanilate. Under halothane anesthesia, sodium arsanilate (15 mg/50 µl) is injected bilaterally with a 33 gauge needle through the tympanic membrane.  

Labryinthectomy is validated behaviorally with two simple tests: 1) the rat is inverted and a Plexiglas sheet apposed to its feet: intact rats right themselves to walk, but a labyrinthectomized rat, even though upside-down, will walk when its feet are in contact with a solid surface; 2) rats are inverted and then dropped 1 m onto a soft foam-rubber cushion: intact rats right themselves in midair and land on their feet, while lesioned rats make no attempt at righting and land on their dorsal side.

Labryinthectomy is validated behaviorally with two simple tests: 1) the rat is inverted and a Plexiglas sheet apposed to its feet: intact rats right themselves to walk, but a labyrinthectomized rat, even though upside-down, will walk when its feet are in contact with a solid surface; 2) rats are inverted and then dropped 1 m onto a soft foam-rubber cushion: intact rats right themselves in midair and land on their feet, while lesioned rats make no attempt at righting and land on their dorsal side.