Changes

Chemical labyrinthectomy is very simple procedure with a near complete destruction of the vestibular apparatus. However, it is very non-specific, destroying both otolithic and semicircular organs, as well as the auditory cochlea [88]. To distinguish the contribution of the various parts of the inner ear, we propose to use mutant mouse strains that have deficits in otolith formation [81] or semicircular canals [13, 89].

Chemical labyrinthectomy is very simple procedure with a near complete destruction of the vestibular apparatus. However, it is very non-specific, destroying both otolithic and semicircular organs, as well as the auditory cochlea [88]. To distinguish the contribution of the various parts of the inner ear, we propose to use mutant mouse strains that have deficits in otolith formation [81] or semicircular canals [13, 89].