SL327

SL327 is a MAP Kinase Kinase 1/2 (MEK1/2) inhibitor.

Sigma-Aldrich S4069-5MG $101

Synonym: α-[Amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile

CAS Number: 305350-87-2

Empirical Formula (Hill Notation): C16H12F3N3S

Molecular Weight: 335.35

MDL number: MFCD06411432

Central Administration

From Kwon and Houpt, 2011:

Dissolve SL327 in 50% DMSO, 50% 0.15M NaCl at 2 ug/ul concentration.. Administer using Hamilton syringe pump over 1 minute: 1 ug/0.5 ul / hemisphere into the CeA immeadiately after 10min access to 0.125% saccharin and 15 min before LiCl injection (12 ml/kg, 0.15 M, i.p.) Inject 0.5 ul over 1 minute; leave injector in place for 1 min after injection to prevent backflow along the injection tract.