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=Disadvantages of c-Fos=
=Disadvantages of c-Fos=
c-Fos expression also has disadvantages. It is a postmortem technique, so the same rat cannot be repeatedly tested. Also, only a subset of activated neurons may be visualized, because some cells do not express c-Fos when activated. Although there are other ways to record or visualize neural activity that avoid these problems, most are impractical when applied to high MFs. Electrophysiological recordings using surface or indwelling metallic electrodes are confounded either by magnetic attraction or by induced currents. Functional MRI, in addition to having relatively low-resolution in small animals, is obviously confounded by the presence of the MF if the field itself is inducing neuronal activity. Other methods of measuring brain activity, such as brain imaging by PET or voltage-sensitive dyes, or neurotransmitter release by microdialysis, would be prohibitively cumbersome to conduct within the confines of the magnet’s bore.
c-Fos expression also has disadvantages. It is a postmortem technique, so the same rat cannot be repeatedly tested. Also, only a subset of activated neurons may be visualized, because some cells do not express c-Fos when activated. Although there are other ways to record or visualize neural activity that avoid these problems, most are impractical when applied to high MFs. Electrophysiological recordings using surface or indwelling metallic electrodes are confounded either by magnetic attraction or by induced currents. Functional MRI, in addition to having relatively low-resolution in small animals, is obviously confounded by the presence of the MF if the field itself is inducing neuronal activity. Other methods of measuring brain activity, such as brain imaging by PET or voltage-sensitive dyes, or neurotransmitter release by microdialysis, would be prohibitively cumbersome to conduct within the confines of the magnet’s bore.
=References=
Brozek, G., O. Buresova, et al. (1974). "Effect of bilateral cortical spreading depression on the hippocampal theta activity induced by oral infusion of aversive gustatory stimulus." Expt. Neurol. 42: 661-668.
Buresova, O., Z. A. Aleksanyan, et al. (1979). "Electrophysiological analysis of retrieval of conditioned taste aversion in rats. Unit activity changes in critical brain regions." Physiol. Bohemoslov. 28: 525-536.
Chang, F.-C. T. and T. R. Scott (1984). "Conditioned taste aversions modify neural responses in the rat nucleus tractus solitarius." J. Neurosci. 4: 1850-1862.
Cirelli, C., M. Popmeiano, et al. (1996). "c-Fos expression in the rat brain after unilateral labyrinthectomy and its relation to the uncompensated and compensated stages." Neurosci. 70: 513-546.
Darlington, C. L., P. Lawlor, et al. (1996). "Temporal relationship between the expression of Fos, Jun and Krox-24 in the guinea pig vestibular nuclei during the development of vestibular compensation for unilateral vestibular deafferentation." Brain Res 735: 173-176.
DiLorenzo, P. M. (1985). "Responses to NaCl of parabrachial units that were conditioned with intravenous LiCl." Chem. Senses 10: 438.
Garcia, J. and R. A. Koelling (1966). "Relation of cue to consequence in avoidance learning." Psychonomic Sci. 4: 123-124.
Gould, J. L. (1998). "Sensory bases of navigation." Current Biology 8: R731-738.
Grigoriadis, A. E., Z.-Q. Wang, et al. (1994). "c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling." Sciecne 266: 443-448.
Gustave Dit Duflo, S., C. Gestreau, et al. (1999). "Fos expression the cat brainstem after unilateral vestibular neurectomy." Brain Res 824: 1-17.
Houpt, T. A., R. A. Berlin, et al. (1997). "Subdiaphragmatic vagotomy does not attenuate c-Fos induction in the nucelus of the solitary tract after conditioned taste aversion expression." Brain Res. 747: 85-91.
Houpt, T. A., J. M. Philopena, et al. (1995). "c-Fos expression in the nucleus of the solitary tract following conditioned taste aversion formation." Appetite 24: 84.
Houpt, T. A., J. M. Philopena, et al. (1996). "c-Fos induction in the rat nucleus of the solitary tract by intraoral quinine infusion depends on prior pairing of quinine and lithium chloride." Physiol. Behav. 60: 1535-41.
Houpt, T. A., J. M. Philopena, et al. (1996). "c-Fos induction in the rat nucleus of the solitary tract correlates with the retention and forgetting of a conditioned taste aversion." Learn. Mem. 3: 25-30.
Houpt, T. A., J. M. Philopena, et al. (1994). "Increased c-Fos expression in the rat nucleus of the solitary tract after conditioned taste aversion formation." Neurosci. Lett. 172: 1-5.
Jones, K. J. and C. Evinger (1991). "Differential neuronal expression of c-fos proto-oncogene following peripheral nerve injury or chemically-induced seizure." J. Neurosci.Res. 28: 291-298.
Kaang, B.-K., E. R. Kandel, et al. (1993). "Activation of cAMP-responsive genes by stimuli that produce long-term facilitation in Aplysia sensory neurons." Neuron 10: 427-435.
Kangarlu, A., r. E. Burgess, et al. (1999). "Cognitive, cardiac, and physiological safety studies in ultra high field magnetic resonance imaging." Magn. Reson. Imag. 17: 1407-1416.
Kaufman, G. D. (1996). "Activation of immediate-early genes by vestibular stimulation." Ann. NY Acad. Sci. 781: 437-442.
Kaufman, G. D., J. H. Anderson, et al. (1991). "Activation of a specific vestibulo-olivary pathway by centripetal acceleration in rat." Brain Res. 562: 311-317.
Kaufman, G. D., J. H. Anderson, et al. (1992). "Fos-defined activity in rat brainstem following centripetal acceleration." J. Neurosci. 12: 4489-4500.
Kaufman, G. D., J. H. Anderson, et al. (1993). "Otolith-brain stem connectivity: evidence for differential neural activation by vestibular hair cells based on quantification of Fos expression in unilateral labyrinthectomized rats." J. Neurophysiol. 70: 117-127.
Kaufman, G. D. and A. A. Perachio (1994). "Translabyrinth electrical stimulation for the induction of immediate early genes in the gerbil brainstem." Brain Res. 646: 345-350.
Kim, M. S., B. K. Jin, et al. (1997). "Effect of MK801 on cFos-like protein expression in the medial vestibular nucleus at early stage of vestibular compensation in uvulonodullectomized rats." Neurosci. Lttrs. 231: 147-150.
Kitahara, T., T. Saika, et al. (1995). "Changes in fos and jun expression in the rat brainstem in the process of vestibular compensation." Acta Otolaryngol. 520: S401-S404.
Kitahara, T., N. Takeda, et al. (1995). "Effects of MK801 on Fos expression in the rat brainstem after unilateral labyrintectomy." Brain Res. 700: 182-190.
Kitahara, T., N. Takeda, et al. (1997). "Role of the flocculus in the development of vestibular compensation: immunohistochemical studies with retograde tracing and flocculectomy using fos expression as a marker in the rat brainstem." Neurosci. 76: 571-580.
Mark, G. P., P. Rada, et al. (1992). "Cholinergic activity in the nucleus accumbens may be inversely related to food intake." Appetite 19: 201.
Marshburn, T. H., G. D. Kaufman, et al. (1997). "Saccule contribution to immediate early gene induction in the gerbil brainstem with posterior canal galvanic or hypergravity stimulation." Brain Res. 761: 51-58.
Morgan, J. I. and T. Curran (1991). "Stimulus-transcription coupling in the nervous system: Involvement of the inducible proto-oncogenes fos and jun." Ann. Rev. Neurosci. 14: 421-451.
Nolte, C. M., D. W. Pittman, et al. (1998). "Magnetic field conditioned taste aversion in rats." Physiol. Behav. 63: 683-688.
Rosenblum, K., D. E. Berman, et al. (1997). "NMDA receptor and the tyrosine phosphorylation of its 2B subunit in taste learning in the rat insular cortex." J. Neurosci. 17: 5129-5135.
Sagar, S. M., F. R. Sharp, et al. (1988). "Expression of c-fos protein in brain: metabolic mapping at the cellular level." Science 240: 1328-1331.
Sato, T., W. Tokuyama, et al. (1997). "Temporal and spatial dissociation of expression patterns between Zif268 and c-Fos in rat inferior olive during vestibular compensation." NeuroReport 8: 1891-1895.
Schafe, G. E. and I. L. Bernstein (1996). "Forebrain contribution to the induction of a brainstem correlate of conditioned taste aversion: I. The amygdala." Brain Res. 741: 109-116.
Schafe, G. E. and B. I.L. (1998). "Forebrain contribution to the induction of a brainstem correlate of conditioned taste aversion. II. Insular (gustatory) cortex." Brain Res. 800: 40-47.
Schafe, G. E., R. J. Seeley, et al. (1995). "Forebrain contributions to the induction of a cellular correlate of conditioned taste aversion in the nucleus of the solitary tract." J. Neurosci. 15: 6789-6796.
Schenck, J. F., C. L. Dumoulin, et al. (1992). "Human exposure to 4.0-Tesla magnetic fields in a whole body scanner." Med. Phys. 19: 1089-1098.
Sheng, M. and M. E. Greenberg (1990). "The regulation and function of c-fos and other immediate early genes in the nervous system." Neuron 7: 477-485.
Swank, M. W. and I. L. Bernstein (1994). "c-Fos induction in response to a conditioned stimulus after single trial taste aversion learning." Brain Res. 636: 202-208.
Swank, M. W., A. E. Ellis, et al. (1996). "c-Fos antisense blocks acquisition and extinction of conditioned taste aversion in mice." Neuroreport 7: 1866-1870.
Swank, M. W., G. E. Schafe, et al. (1995). "c-Fos induction in response to taste stimuli previously paired with amphetamine or LiCl during taste aversion learning." Brain Res. 673: 251-261.
Thiele, T. E., M. F. Roitman, et al. (1996). "c-Fos induction in rat brainstem in response to ethanol- and lithium chloride-induced conditioned taste aversions." Alcohol. Clin. Exp. Res. 20: 1023-1028.
Walker, M. M., C. E. Diebel, et al. (1997). "Structure and function of the vertebrate magnetic sense." Nature 390: 371-376.
Weiser, M., H. Baker, et al. (1993). "Axotomy-induced differential gene induction in neurons of the locus ceruleus and substantia nigra." Mol. Brain Res. 17: 319-327.
Yamamoto (1989). "Taste responses of cortical neurons in freely ingesting rats." J. Neurophysiol. 61: 1244-1258.
Yamamoto, T., T. Shimura, et al. (1991). "Role of the amygdala in conditioned taste avesion learning in the rat." Neurosci. Res. Suppl. 16: S140.