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Incorporation of BrdU makes cells more sensitive to radiation damage.
 
Incorporation of BrdU makes cells more sensitive to radiation damage.
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=Pharmacokinetics=
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Papers to look up re: pharmacokinetics
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1:
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The toxic effect of 5-bromodeoxyuridine on cultured epithelial cells.
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LITTLEFIELD JW, GOULD EA.
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J Biol Chem. 1960 Apr;235:1129-33. No abstract available.
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PMID 14417553 [PubMed - OLDMEDLINE]
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Related Articles Free article at journal site
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2:
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Relative stability to thermal denaturation of deoxyribonucleic acid (DNA) preparations containing bromodeoxyuridine.
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KIT S, HSU TC.
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Biochem Biophys Res Commun. 1961 Jun 2;5:120-4. No abstract available.
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PMID 13756434
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3:
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Quantitative studies of incorporation of exogenous thymidine and 5-bromodeoxyuridine into deoxyribonucleic acid of mammalian cells in vitro.
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KRISS JP, REVESZ L.
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Cancer Res. 1961 Oct;21:1141-7. No abstract available.
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PMID 14459708
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4:
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Incorporation of unnatural pyrimidine bases into deoxyribonucleic acid of mammalian cells.
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EIDINOFF ML, CHEONG L, RICH MA.
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Science. 1959 Jun 5;129(3362):1550-1.
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PMID 13658990
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5:
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The fate of 5-bromodeoxyuridine, 5-bromodeoxycytidine, and 5-iododeoxycytidine in man.
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KRISS JP, MARUYAMA Y, TUNG LA, BOND SB, REVESZ L.
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Cancer Res. 1963 Feb;23:260-8. No abstract available.
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PMID 14035826  Free article at journal site
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6:
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Effect of 5-bromodeoxyuridine incorporation on survival of cultured mammalian cells.
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HAKALA MT.
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Biochim Biophys Acta. 1962 Nov 26;61:815-23. No abstract available.
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PMID 13952011 [PubMed - OLDMEDLINE]
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Related Articles
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7:
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A chromosome study of radiation sensitization by 5-bromodeoxyuridine.
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SOMERS CE, HUMPHREY RM.
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Exp Cell Res. 1963 Mar;30:208-17. No abstract available.
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PMID 13978156
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8:
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Radiosensitization of a mammalian cell line with 5-bromodeoxyuridine.
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DELIHAS N, RICH MA, EIDINOFF ML.
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Radiat Res. 1962 Oct;17:479-91. No abstract available.
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PMID 14026711 [PubMed - OLDMEDLINE]
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Related Articles
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9:
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The distribution and fate of bromodeoxyuridine and bromodeoxycytidine in the mouse and rat.
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KRISS JP, REVESZ L.
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Cancer Res. 1962 Feb;22:254-65. No abstract available.
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PMID 14459709  Free article at journal site
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10:
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Increase in radiosensitivity to ionizing radiation related to replacement of thymidine in mammalian cells with 5-bromodeoxyuridine.
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Dewey WC, Humphrey RM.
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Radiat Res. 1965 Dec;26(4):538-53. No abstract available.
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PMID 5849707
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11:
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Structures of 5-bromodeoxyuridine and 5-bromouridine.
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Iball J, Morgan CH, Wilson HR.
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Nature. 1966 Mar 19;209(5029):1230-2. No abstract available.
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PMID 5956313
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12:
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Intra-arterial 5-bromodeoxyuridine and x-ray therapy.
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Bagshaw MA, Doggett RL, Smith KC, Kaplan HS, Nelsen TS.
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Am J Roentgenol Radium Ther Nucl Med. 1967 Apr;99(4):886-94. No abstract available.
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PMID 6021392
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13:
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Theoretical evaluation of a limitation in the use of pyrimidine analogs in radiation therapy.
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Suit HD.
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Radiology. 1966 Dec;87(6):1065-8 passim. No abstract available.
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PMID 5926229
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14:
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Comparative aspects of the pharmacology of the antimetabolites.
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Karnofsky DA, Young CW.
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Fed Proc. 1967 Jul-Aug;26(4):1139-45. No abstract available.
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PMID 4226285
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15:
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Loss of labelled DNA from rat brain following injections of precursors with high specific radioactivity. II. DNA labelled with 5-[131I]iodo-2'-deoxyuridine and 5-[82Br]bromo-2'-deoxyuridine.
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Merits I, Cain JC.
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Biochim Biophys Acta. 1970;209(2):327-38. No abstract available.
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PMID 5453521
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16:
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The turnover of isotopically labelled DNA in vivo in developing, adult and Scrapie-affected mouse brain.
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Kimberlin RH, Shirt DB, Collis SC.
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J Neurochem. 1974 Jul;23(1):241-8. No abstract available.
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PMID 4859554
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17:
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Comparison of bromodeoxyuridine labeling indices obtained from tissue sections and flow cytometry of brain tumors.
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Nagashima T, Hoshino T, Cho KG, Senegor M, Waldman F, Nomura K.
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J Neurosurg. 1988 Mar;68(3):388-92.
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PMID 3278075
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18:
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Improvement of the bioavailability of the anti-herpes virus agent BVDU by use of 5'-O-alkoxycarbonyl derivatives with increased metabolic stability.
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Boyd MR, Cole M, Harnden MR, Luk K, Rush MA, Sutton D, Hodge RA.
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J Antimicrob Chemother. 1986 Oct;18 Suppl B:207-13.
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PMID 3793660
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19:
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Cell kinetic studies of in situ human brain tumors with bromodeoxyuridine.
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Hoshino T, Nagashima T, Murovic J, Levin EM, Levin VA, Rupp SM.
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Cytometry. 1985 Nov;6(6):627-32.
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PMID 2998714
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20:
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Bioavailability of bromodeoxyuridine in dogs and toxicity in rats.
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Phuphanich S, Levin VA.
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Cancer Res. 1985 May;45(5):2387-9. No abstract available.
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PMID 3986781  Free article at journal site
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21:
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Pharmacological evaluation of intravenous delivery of 5-bromodeoxyuridine to patients with brain tumors.
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Russo A, Gianni L, Kinsella TJ, Klecker RW Jr, Jenkins J, Rowland J, Glatstein E, Mitchell JB, Collins J, Myers C.
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Cancer Res. 1984 Apr;44(4):1702-5.
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PMID 6704976  Free article at journal site
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22:
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Incorporation and persistence of 5-bromodeoxyuridine in newborn rat tissue DNA.
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Likhachev AJ, Tomatis L, Margison GP.
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Chem Biol Interact. 1983 Aug 15;46(1):31-8.
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PMID 6616707
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23:
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Incorporation of 5-bromodeoxyuridine into DNA in newborn rat tissues.
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Margison GP, Likhachev AJ, Tomatis L.
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Chem Biol Interact. 1980 Jun;30(3):297-303.
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PMID 7379209
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24:
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Tumor uptake of radiolabeled pyrimidine bases and pyrimidine nucleosides in animal models--III. 2'-[82Br]-bromo-2'-deoxyuridine.
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Lee YW, Knaus EE, Wiebe LI.
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Int J Nucl Med Biol. 1979;6(2):109-112. No abstract available.
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PMID 113355
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25:
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Bromodeoxyuridine incorporation into DNA of human leukemia cells is not concentration dependent.
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Powell BL, Gregory BW, Kute TE, Morgan TM, Lyerly ES, Capizzi RL.
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Cytometry. 1990;11(3):438-41.
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PMID 2340778
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26:
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Immunocytochemical detection of 5'-bromodeoxyuridine incorporation in the central nervous system of the mouse.
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del Rio JA, Soriano E.
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Brain Res Dev Brain Res. 1989 Oct 1;49(2):311-7.
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PMID 2805336
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27:
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In situ analysis of cell kinetics in human brain tumors. A comparative immunocytochemical study of S phase cells by a new in vitro bromodeoxyuridine-labeling technique, and of proliferating pool cells by monoclonal antibody Ki-67.
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Morimura T, Kitz K, Budka H.
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Acta Neuropathol. 1989;77(3):276-82.
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PMID 2922990
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28:
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Steady-state arterial and hepatic venous plasma concentrations of 5-bromo-2'-deoxyuridine and 5-iodo-2'-deoxyuridine in animals--drugs which are subject to both splanchnic and extra-splanchnic elimination.
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Wagner JG, Stetson PL, Knol JA, Andrews JC, Walker-Andrews S, Knutsen CA, Johnson N, Prieskorn D, Terrio P, Yang Z, et al.
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Sel Cancer Ther. 1989 Winter;5(4):193-203.
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PMID 2623384
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29:
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Tissue-specific pharmacodynamics of 5-bromo-2'-deoxyuridine incorporation into DNA in VX2 tumor-bearing rabbits.
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Stetson PL, Maybaum J, Wagner JG, Averill DR, Wollner IS, Knol JA, Johnson NJ, Yang ZM, Preiskorn D, Smith P, et al.
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Cancer Res. 1988 Dec 1;48(23):6900-5.
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PMID 3180098  Free article at journal site
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30:
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Persistence of 5-bromo-2'-deoxyuridine in tissues of rats after exposure in early life.
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Ward JM, Henneman JR, Osipova GYu, Anisimov VN.
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Toxicology. 1991;70(3):345-52.
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PMID 1771641
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31:
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cis-trans-isomerization of [E]-5-(2-bromovinyl)-2,2'-anhydrouridine in vivo in rats.
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Szinai I, Veres Z, Szabolcs A, Gács-Baitz E, Ujszászy K, Dénes G.
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Xenobiotica. 1991 Mar;21(3):359-69.
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PMID 1650515
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32:
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The dependence of halogenated pyrimidine incorporation and radiosensitization on the duration of drug exposure.
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Lawrence TS, Davis MA, Maybaum J, Stetson PL, Ensminger WD.
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Int J Radiat Oncol Biol Phys. 1990 Jun;18(6):1393-8.
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PMID 2370189
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33:
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Cyclization-activated prodrugs. Basic esters of 5-bromo-2'-deoxyuridine.
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Saari WS, Schwering JE, Lyle PA, Smith SJ, Engelhardt EL.
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J Med Chem. 1990 Sep;33(9):2590-5.
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PMID 2391697
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34:
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Effect of lithium on incorporation of bromodeoxyuridine and tritiated thymidine into human parathyroid cells.
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Saxe A, Gibson G.
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Arch Surg. 1993 Aug;128(8):865-9.
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PMID 8343059
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35:
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Evaluation of a new lipophilic prodrug 3', 5'-dioctanoyl-5-bromodeoxyuridine (BrdU-C8) suspended in Lipiodol as a radiosensitizer for the treatment of AH136B tumor.
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Ohara C, Beppu T, Yamaguchi Y, Masuda Y, Fukushima S, Kawaguchi T, Ogawa M.
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Anticancer Res. 1993 May-Jun;13(3):655-60.
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PMID 8391245
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36:
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Measurement of incorporation of bromodeoxyuridine into DNA by high performance liquid chromatography using a novel fluorescent labelling technique.
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Stratford MR, Dennis MF.
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Int J Radiat Oncol Biol Phys. 1992;22(3):485-7.
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PMID 1735684
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37:
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Kinetics of bromodeoxyuridine elimination from human colon cancer cells in vitro and in vivo.
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Lawrence TS, Davis MA, Stetson PL, Maybaum J, Ensminger WD.
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Cancer Res. 1994 Jun 1;54(11):2964-8.
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PMID 8187082  Free article at journal site
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38:
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Differential expressions of the topoisomerase II alpha and II beta mRNAs in developing rat brain.
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Watanabe M, Tsutsui K, Tsutsui K, Inoue Y.
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Neurosci Res. 1994 Feb;19(1):51-7.
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PMID 8008235
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39:
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Preparation, characterization and release of microencapsulated bromodeoxyuridine.
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Maysinger D, Filipović-Grcić J, Alebić-Kolbah T.
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Life Sci. 1994;54(1):27-34.
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PMID 8255166
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40:
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Regional differences in bromodeoxyuridine uptake, expression of Ki-67 protein, and nucleolar organizer region counts in glioblastoma multiforme.
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Onda K, Davis RL, Wilson CB, Hoshino T.
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Acta Neuropathol. 1994;87(6):586-93.
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PMID 8091951
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41:
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The application of 5-bromodeoxyuridine in the management of CNS tumors.
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Freese A, O'Rourke D, Judy K, O'Connor MJ.
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J Neurooncol. 1994;20(1):81-95. Review.
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PMID 7807187
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42:
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Comparison of bromodeoxyuridine uptake and MIB 1 immunoreactivity in medulloblastomas determined with single and double immunohistochemical staining methods.
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Onda K, Davis RL, Edwards MS.
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J Neurooncol. 1996 Aug;29(2):129-36.
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PMID 8858517
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43:
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Incorporation of 5-iodo-2'-deoxyuridine and 5-bromo-2'-deoxyuridine into rodent DNA as determined by neutron activation analysis.
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Kitchin KT, Brown JL.
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Anal Biochem. 1995 Aug 10;229(2):180-7.
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PMID 7485970
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44:
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Pharmacokinetics and bioavailability of 5-ethyl-2'-deoxyuridine and its novel (5R,6R)-5-bromo-6-ethoxy-5,6-dihydro prodrugs in mice.
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Cheraghali AM, Kumar R, Knaus EE, Wiebe LI.
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Drug Metab Dispos. 1995 Feb;23(2):223-6.
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PMID 7736915
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45:
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Long-term oral application of 5-bromo-2-deoxyuridine does not reliably label proliferating immune cells in the LEW rat.
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Jecker P, Beuleke A, Dressendörfer I, Pabst R, Westermann J.
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J Histochem Cytochem. 1997 Mar;45(3):393-401.
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PMID 9071321  Free article at journal site
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46:
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Fluorescein-labeled tyramide strongly enhances the detection of low bromodeoxyuridine incorporation levels.
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Van Heusden J, de Jong P, Ramaekers F, Bruwiere H, Borgers M, Smets G.
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J Histochem Cytochem. 1997 Feb;45(2):315-9.
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PMID 9016320  Free article at journal site
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47:
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Regional pharmacokinetics of 5-bromo-2'-deoxyuridine and 5-fluorouracil in dogs: hepatic arterial versus portal venous infusions.
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Kuan HY, Smith DE, Ensmiger WD, Knol JA, DeRemer SJ, Yang Z, Stetson PL.
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Cancer Res. 1996 Oct 15;56(20):4724-7.
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PMID 8840990  Free article at journal site
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48:
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Bromodeoxyuridine uptake by early liver metastases in rats: a comparison of the hepatic artery and portal vein infusion routes.
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Ishida H, Iwama T, Yoshinaga K, Gonda T, Idezuki Y.
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Surg Today. 1998;28(8):822-9.
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PMID 9719004
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49:
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Assessment of correlation between skin target site free drug concentration and the in vivo topical antiviral efficacy in hairless mice for (E)-5-(2-bromovinyl)-2'-deoxyuridine and acyclovir formulations.
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Afouna MI, Mehta SC, Ghanem AH, Higuchi WI, Kern ER, De Clercq E, El-Shattawy HH.
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J Pharm Sci. 1998 Aug;87(8):917-21.
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PMID 9687333
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50:
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Changes in cell-cycle kinetics during the development and evolution of primate neocortex.
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Kornack DR, Rakic P.
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Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1242-6.
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PMID 9448316  Free article in PMC | at journal site
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51:
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Bromodeoxyuridine alternating with radiation for advanced uterine cervix cancer: a phase I and drug incorporation study.
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Eisbruch A, Robertson JM, Johnston CM, Tworek J, Reynolds KR, Roberts JA, Lawrence TS.
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J Clin Oncol. 1999 Jan;17(1):31-40.
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PMID 10458215
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52:
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Determination of (E)-5-(2-bromovinyl)-2'-deoxyuridine in plasma and urine by capillary electrophoresis.
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Olgemöller J, Hempel G, Boos J, Blaschke G.
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J Chromatogr B Biomed Sci Appl. 1999 Apr 16;726(1-2):261-8.
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PMID 10348194
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53:
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Elimination of nonspecific radioactivity from [76Br]bromide in PET study with [76Br]bromodeoxyuridine.
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Lu L, Bergström M, Fasth KJ, Wu F, Eriksson B, Långström B.
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Nucl Med Biol. 1999 Oct;26(7):795-802.
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PMID 10628559
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54:
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[76Br]Bromodeoxyuridine, a potential tracer for the measurement of cell proliferation by positron emission tomography, in vitro and in vivo studies in mice.
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Ryser JE, Bläuenstein P, Rémy N, Weinreich R, Hasler PH, Novak-Hofer I, Schubiger PA.
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Nucl Med Biol. 1999 Aug;26(6):673-9.
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PMID 10587106
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55:
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Analysis of 76Br-BrdU in DNA of brain tumors after a PET study does not support its use as a proliferation marker.
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Gudjonssona O, Bergström M, Kristjansson S, Wu F, Nyberg G, Fasth KJ, Långström B.
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Nucl Med Biol. 2001 Jan;28(1):59-65.
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PMID 11182565
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56:
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[76Br]Bromodeoxyuridine PET in tumor-bearing animals.
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Gardelle O, Roelcke U, Vontobel P, Crompton NE, Guenther I, Bläuenstein P, Schubiger AP, Blattmann H, Ryser JE, Leenders KL, Kaser-Hotz B.
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Nucl Med Biol. 2001 Jan;28(1):51-7.
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PMID 11182564
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57:
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Use of 5-[(76)Br]bromo-2'-fluoro-2'-deoxyuridine as a ligand for tumour proliferation: validation in an animal tumour model.
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Borbath I, Grégoire V, Bergström M, Laryea D, Långström B, Pauwels S.
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Eur J Nucl Med Mol Imaging. 2002 Jan;29(1):19-27. Epub 2001 Nov 22.
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PMID 11807603
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58:
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A method for pulse and chase BrdU-labeling of early chick embryos.
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Hämmerle B, Tejedor FJ.
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J Neurosci Methods. 2002 Dec 31;122(1):59-64.
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PMID 12535764
 +
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59:
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Label-retaining cells in the rat pancreas: location and differentiation potential in vitro.
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Duvillié B, Attali M, Aiello V, Quemeneur E, Scharfmann R.
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Diabetes. 2003 Aug;52(8):2035-42.
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PMID 12882920  Free article at journal site
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60:
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Brivudine: a herpes virostatic with rapid antiviral activity and once-daily dosing.
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Rabasseda X.
 +
Drugs Today (Barc). 2003 May;39(5):359-71. Review.
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PMID 12861349
 +
 +
61:
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Visualization of proliferating cells in the adult mammalian brain with the aid of ribonucleotide reductase.
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Zhu H, Wang ZY, Hansson HA.
 +
Brain Res. 2003 Jul 11;977(2):180-9.
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PMID 12834878
 +
 +
62:
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Tumor distribution of bromodeoxyuridine-labeled cells is strongly dose dependent.
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Kyle AH, Huxham LA, Baker JH, Burston HE, Minchinton AI.
 +
Cancer Res. 2003 Sep 15;63(18):5707-11.
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PMID 14522888  Free article at journal site
 +
 +
63:
 +
Direct assessment of drug penetration into tissue using a novel application of three-dimensional cell culture.
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Kyle AH, Huxham LA, Chiam AS, Sim DH, Minchinton AI.
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Cancer Res. 2004 Sep 1;64(17):6304-9.
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PMID 15342419  Free article at journal site
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 +
64:
 +
Thymidine analogs are transferred from prelabeled donor to host cells in the central nervous system after transplantation: a word of caution.
 +
Burns TC, Ortiz-González XR, Gutiérrez-Pérez M, Keene CD, Sharda R, Demorest ZL, Jiang Y, Nelson-Holte M, Soriano M, Nakagawa Y, Luquin MR, Garcia-Verdugo JM, Prósper F, Low WC, Verfaillie CM.
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Stem Cells. 2006 Apr;24(4):1121-7. Epub 2005 Dec 22.
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PMID 16373692  Free article at journal site
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65:
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Gadofluorine m uptake in stem cells as a new magnetic resonance imaging tracking method: an in vitro and in vivo study.
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Giesel FL, Stroick M, Griebe M, Tröster H, von der Lieth CW, Requardt M, Rius M, Essig M, Kauczor HU, Hennerici MG, Fatar M.
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Invest Radiol. 2006 Dec;41(12):868-73.
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PMID 17099425
 +
 +
66:
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Ki-67 correlates with in vivo bromodeoxyuridine labeling index in operable breast cancer.
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Goodson WH, Moore DH, Waldman FM.
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J Clin Oncol. 2006 Aug 10;24(23):3809; author reply 3809. No abstract available.
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PMID 16896010
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67:
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An ELISA-based method for the quantification of incorporated BrdU as a measure of cell proliferation in vivo.
 +
Behl B, Klos M, Serr M, Ebert U, Janson B, Drescher K, Gross G, Schoemaker H.
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J Neurosci Methods. 2006 Nov 15;158(1):37-49. Epub 2006 Jun 15.
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PMID 16780957
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68:
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Dienogest inhibits BrdU uptake with G0/G1 arrest in cultured endometriotic stromal cells.
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Fu L, Osuga Y, Morimoto C, Hirata T, Hirota Y, Yano T, Taketani Y.
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Fertil Steril. 2008 May;89(5 Suppl):1344-7. Epub 2007 May 23.
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PMID 17511992
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69:
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Bromodeoxyuridine labeling index as an indicator of early tumor response to preoperative radiotherapy in patients with rectal cancer.
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Gasinska A, Skolyszewski J, Popiela T, Richter P, Darasz Z, Nowak K, Niemiec J, Biesaga B, Adamczyk A, Bucki K, Malecki K, Reinfuss M, Kowalska T.
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J Gastrointest Surg. 2007 Apr;11(4):520-8.
 +
PMID 17436139  Free article in PMC | at journal site
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70:
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The origin of deoxynucleosides in brain: implications for the study of neurogenesis and stem cell therapy.
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Spector R, Johanson CE.
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Pharm Res. 2007 May;24(5):859-67. Epub 2007 Mar 20. Review.
 +
PMID 17372683
    
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