VTA Cell Counts

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Cell counts for total number of cells and TH-positive cells in the VTA of rats from the literature.

Paper Total Neurons TH+ Cells TH cells /mm2 TH cells/ mm3 Technique
Gondré-Lewis 2016 61,000 ± 3700 252 ± 13 Stereology for total neurons, IHC for TH cells
Gomide 2005 12,000 ± 1600 1,190 ± 130 Stereology (typo in volume — paper says x10, not x1000)
Healy-Stoffel 2014 16,641±567 1,724±81 Stereology
Mukherjee pilot 71 15,625 IHC, extrapolating from 40 um section

References

Gondré-Lewis et al., Stereological Analyses of Reward System Nuclei in Maternally Deprived/Separated Alcohol Drinking Rats J Chem Neuroanat. 2016 October ; 76(Pt B): 122–132 PMID 26939765

Healy-Stoffel et al. Differential Effects of Intrastriatal 6- Hydroxydopamine on Cell Number and Morphology in Midbrain Dopaminergic Subregions of the Rat Brain Res. 2014 Jul 29;1574:113-9 PMID 24924804

Gomide et al. Dopamine cell morphology and glial cell hypertrophy and process branching in the nigrostriatal system after striatal 6-OHDA analyzed by specific sterological tools. Int J Neurosci. 2005 Apr;115(4):557-82. PMID 15804725