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Chronic toxicity occurs with daily intakes of more than 100,000 IU for more than 6 months, or more than 25 000 IU for more than 6 years.
Chronic toxicity occurs with daily intakes of more than 100,000 IU for more than 6 months, or more than 25 000 IU for more than 6 years.
Rodahl (1949) reported on the acute and chronic effects of vitamin A in rats, mice, guinea pigs, rabbits, dogs and chickens. "Within a few hors after single doses in the range 50-100 I.U. vitaimn A/gm body weight [166-332 mg/kg], aymptoms of acute intoxication occurred in the form of general malady, changes in the pelts, drwosiness, muscular weakness and decreased activity."
'''References'''
'''References'''
Institute of Medicine, Food and Nutrition Board. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academy Press; 2001:65-126.
Institute of Medicine, Food and Nutrition Board. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academy Press; 2001:65-126.
Rodahl, K. Hypervitaminosis A and scurvy. Nature 164 (1949) 531.