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C-Fos Posttranslational Modifications (view source)
Revision as of 15:06, 3 December 2008
, 15:06, 3 December 2008→Phosphorylation
==Phosphorylation==
==Phosphorylation==
c-Fos serine/threonine (ser/thr) phosphorylation has been extensively studied in the past two decades (Herdegen and Leah, 1998; Jacobs et al., 1999) linking this phenomenon to protein stability (Gius et al., 1990; Tsurumi et al., 1995), signal transduction (Stork, 2002; Tanos et al., 2005) and transactivation capacity (Allegretto et al., 1990; Abate et al., 1993). From Portal et al 2006 PMID 17160021 for the references
===tyrosine 10 and tyrosine 30===
From Portal et al 2006 PMID 17160021
Fetal bovin serum causes rapid dephosphorylation of phospho-tyrosine c-Fos (this is the opposite of activation-induced ser/thr phosphorylation)
====Effect====
phosphotyrosine keeps c-Fos in the soluble fraction; dephosphorylation causes c-Fos to associate with endoplasmic reticulum (important for c-Fos-dependent activation of phospholipid synthesis)
====Regulation====
phosphorylation is increased with phenylarsine oxide (PAO), an inhibitor of tyr phosphatases
==Sumoylation==
==Sumoylation==