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C-Fos Posttranslational Modifications (view source)
Revision as of 16:22, 3 December 2008
, 16:22, 3 December 2008→Phosphorylation: added some general ser/thr notes
c-Fos serine/threonine (ser/thr) phosphorylation has been extensively studied in the past two decades (Herdegen and Leah, 1998; Jacobs et al., 1999) linking this phenomenon to protein stability (Gius et al., 1990; Tsurumi et al., 1995), signal transduction (Stork, 2002; Tanos et al., 2005) and transactivation capacity (Allegretto et al., 1990; Abate et al., 1993). From Portal et al 2006 PMID 17160021 for the references
c-Fos serine/threonine (ser/thr) phosphorylation has been extensively studied in the past two decades (Herdegen and Leah, 1998; Jacobs et al., 1999) linking this phenomenon to protein stability (Gius et al., 1990; Tsurumi et al., 1995), signal transduction (Stork, 2002; Tanos et al., 2005) and transactivation capacity (Allegretto et al., 1990; Abate et al., 1993). From Portal et al 2006 PMID 17160021 for the references
Abate et al 1991 PMID 1766667 describes phosphorylation of c-Fos in vitro by PKA, PKC, and p34cdc2 (need to get the paper)
Abate et al 1993 PMID 8341696 describe regulation of c-fos phosphorylation by dimerization with c-Jun and binding to AP-1 oligo: phospho-c-Fos is not much regulated, although phospho- c-jun is altered by dimerization or DNA binding.
(need to put this in a nice table)
kinase Fos fos/jun Fos/Jun/AP-1
cdc2 100 100 50
PKC 100 100 100
PKA 100 100 100
p44 mapk 100 100 100
DNA-PK 0 0 100
===tyrosine 10 and tyrosine 30===
===tyrosine 10 and tyrosine 30===