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C-Fos Posttranslational Modifications (view source)
Revision as of 16:49, 3 December 2008
, 16:49, 3 December 2008→Phosphorylation: added more ser/thr details
DNA-PK 0 0 100
DNA-PK 0 0 100
===Ser374 and Ser362 ===
From Pellegrino Stork 2006 PMID 17223854
====Effect====
In the C-terminus, can stabilize c-Fos by interfering with degradation, and act as 'priming' phosphorylations that help potentiate phosphorylation with the transactivation domain (Thr325, Thr331, and maybe Thr232)
====Regulation====
Ser374 phosphorylated by ERKs in vitro and in vivo Chen 1996
Ser362 phosphorylated by ERK-dependent RSK, but NOT phosphorylated by ERK directly in vitro (Monje et al. 2003),.
===Thr325 and Thr331 ===
From Pellegrino Stork 2006 PMID 17223854
====Effect====
within the transactivation domain potentiate AP-1-dependent transcription (Monje et al. 2003)
====Regulation====
phosphorylated by ERKs (although less sure about Thr331)
depends on the the binding of ERKs to an ERK targeting domain, also known as a DEF domain
===Thr232===
From Pellegrino Stork 2006 PMID 17223854
====Effect====
enhances c-Fos transactivation
====Regulation====
Thr232 is phosphorylated by unknown kinase (NOT ERK1/2)
===tyrosine 10 and tyrosine 30===
===tyrosine 10 and tyrosine 30===