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added drug prep
6-azauracil MW 113.07 [https://www.sigmaaldrich.com/US/en/product/sigma/a1757 Sigma A1757-5g] $99.90: UMPS inhibitor
6-azauracil MW 113.07 [https://www.sigmaaldrich.com/US/en/product/sigma/a1757 Sigma A1757-5g] $99.90: UMPS inhibitor
For injection, combine 100 mg/kg naringin (17mM) + 30 mg/kg 6-azauracil (27mM) dissolved in saline; in 10 ml/kg i.p. injection.
For injection, combine 100 mg/kg naringin (17mM) + 30 mg/kg 6-azauracil (27mM) dissolved in saline/10% DMSO; in 10 ml/kg i.p. injection.
* measure 400mg naringin + 120mg 6-azuracil;
* dissolve in 4ml DMSO with heavy vortexing
* slowly add 36 ml sterile injectable 0.9% saline, with frequent vortexing (-> clear light yellow solution)
* filter
Use 10% DMSO in injectable 0.9% saline as vehicle control.